It’s Not Where, it’s What: Targeted Oncology and the Keys to Solving Cancer

Rather than treating cancer based on its location in the body, scientists have found another, more effective, more targeted way to treat cancer — one that you need a code to unlock. On this episode we look at the surprising history and the hopeful future of immunotherapy, and how the genetic code of cancer itself is being used. We speak with  Jefferies’ Mike Yee, Johns Hopkins’ Neeha Zaidi, and Neville Sanjana from the NY Genome Center.

When Your Home is the Hospital: Tech-Enabled Healing

One of the fastest-growing areas of healthcare is focusing less on what’s wrong with you, but where the healing actually happens. In this episode we learn about innovation beyond the drugs – how doctors are providing medical care right to a patient’s front door. We speak with Jefferies’ Brian Tanquilut, Medically Home’s Raphael Rakowski, and Professor and author Elizabeth Krupinski of Emory University.

Cracking the Code that Runs Us: The Future of Gene Therapy

The discovery of DNA in the 1850’s allowed us to see into the genetic code of individual humans. Fast forward to the 21st century, scientists are developing a technique to rewrite those genes. In this episode, we look at the ways gene editing is being used to turn that century-old breakthrough into the future of medicine. We speak with Jefferies’ Will Sevush, Beam Therapeutics’ Pino CiarmellaNeville Sanjana from the NY Genome Center, and Dr. Paul Offit at the Children’s Hospital of Philadelphia.

Breaking the Blood Brain Barrier: The Quest to Cure Neurodegeneration

Neurological degenerative illnesses like Alzheimer’s, Parkinson’s and ALS have proven difficult to treat because of one of the strongest security systems in the human body: The Blood Brain Barrier. This episode looks at how modern medicine might be able to finally break down that barrier for good. We speak with Jefferies’ Mike Yee, Denali Therapeutics’ Ryan Watts, and Dr. Rachita Sumbria of Chapman University.

From Zero to Hero: The Story Behind the mRNA Vaccine

This new season kicks off with a medical breakthrough story you might THINK you know, but isn't so straightforward. The "speedy" development of mRNA technology, behind many Covid-19 vaccines, actually took decades of twists and turns. We speak with Jefferies’ Mike Yee, Acuitas Therapeutics’ Thomas Madden, and Joe Miller of the Financial Times.

Bonus Episode: Hopeless Optimism

Throughout this season, we highlight medical breakthroughs stemming from investment: of time, of money, of research and ingenuity. Exploring the common thread that links all these incredible stories together: the alchemy that brings about these life-saving innovations in healthcare. We speak with Jefferies’ Mike Yee and Will Sevush, Johns Hopkins’ Neeha Zaidi, and Dr. Rachita Sumbria of Chapman University.

Season 3 Trailer: What Healthcare Breakthrough Are You Waiting For?

Invisible Forces is a podcast that investigates the unseen influences that drive our spending, our saving and our global economy. Hosted by Jefferies’ insider Shannon Murphy, season three is all about one invisible force – the alchemy that can turn a series of unlikely events, surprises and setbacks into medicine’s biggest successes. We’ll hear from biotech industry leaders and our own Jefferies experts about some of the biggest breakthroughs in medical history – and the investments that brought them into reality.

An All-Encompassing Economy

2020 will be remembered for many reasons – and a main one is that the conversation around racial injustice hit a breaking point. COVID-19 exacerbated inequities in health outcomes for Black and Latino Americans, and in the wake of George Floyd’s death, we’ve seen a massive movement for enduring change. Consumers are seeking ways to support Black-owned businesses with their dollars, and Kristina Liburd (Founder & CEO of Viageur) and Boyuan Gao (Founder & Principle of Project Inkblot) speak to how companies are looking to hire more equitably and inclusively. Stephanie Wemusa (VP Diversity & Inclusion at TalVista) and Evie Cheung (Designer at Doblin) discuss how even our technology is getting a redesign – to correct biases built right into the programming of tech tools companies and consumers use every day, such as smart voice assistants and hiring platforms. Jefferies’ Head of Global Corporate Access, and Founder & Head of J-NOBLE – Jefferies Network of Black and Latinx employees, Nadia Batchelor, explores how this powerful movement can create lasting changes in businesses around the world.

A New Peace of Mind

2020 has been a year of instability and upheaval, so it’s no surprise many of us have been especially focused on our security – securing our health, our homes, our digital lives, and even our finances. We used to talk about ‘safety in numbers’ – but during the pandemic as we’ve been in quarantine and isolation – we’ve had to rethink what security looks and feels like today. Jefferies’ European Head of Investment Banking, Dominic Lester, and Global Head of Information Securty, Ramin Safai, are joined by Christian Cerda, the CEO of Simplisafe and Thomas Smyth, founder and CEO of Trim. In this episode, we explore how this need for fortification has been accelerated by work-from-home orders and lockdowns, and how this year has changed our idea of security for good.

Lean, Mean and Green: The Future of Sustainable Businesses

Consumers today, especially younger buyers, are in the market for more environmentally friendly products – and the good news is, their options are only growing. This episode looks at how the trend towards conscious consumption is driving change in just about every industry, from fashion, to food, to home decor. Simon Powell, Jon Matuszewski, and Dominic Lester are joined by Tom Quinn, the President of Halio North America, Erin Wallace, the VP of Integrated Marketing at Thred Up and Thrive Market CEO Nick Green, to dig into how tech is powering green innovations in a wide range of industries. We hear from business leaders how this force is not only good for the Earth, but good for your company's bottom line. As the buying power of Gen Z and Millennials grows into the trillions, how will this trend change our markets over the next decade?

The Changing Face of Urban Space

The global pandemic has made many of us think differently about the cities we live in. As lockdowns closed many of the amenities that make cities desirable, work-from-home orders showed us we can really work from anywhere. In this episode, we explore the future of our cities, and how the push-pull of urbanization will shake out over the coming years. Jon Matuszewski, Storm Duncan and Nadia Batchelor join to discuss whether the city-dwellers considering swapping skylines for suburbs will really move, and what implications this may have on the future of city space? Taco Carlier, the co-founder of the Dutch e-bike company Van Moof explores what the pandemic might do for the future of urban transportation? 

When Tech is Your Tailor

In 2020, personalization has become a dominant trend across industries. It is an effective way to grow your market, boosting sales, customer satisfaction and brand loyalty, all while minimizing costs and overhead. Jefferies experts Cameron Lester and Jared Holz explore how the shift towards hyper-personalized goods and services is revolutionizing the retail and healthcare landscapes. They are joined by Nick Green, the co-founder and CEO of Thrive Market, Chris Merkle, the co-founder of MIME, and Dr. William Li, a physician and bestselling author of Eat to Beat Disease.